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. 2015 May 5;108(9):2171–2180. doi: 10.1016/j.bpj.2015.03.044

Figure 4.

Figure 4

Effect of PKCα inhibition on OHC length. Electrically stimulated OHCs showed a decrease in total length (slow motility). (A) OHC shortening versus time in control (n = 5), LPA treated (n = 5), and LPA+BIM-1-treated (10 μM, n = 5) OHCs. Whereas LPA increased cell shortening, pretreatment with BIM-1 partially modified this response. (B) Cell shortening values (total cell length = 100%) at 3 s after the beginning of the stimulation (mean ± SE): control = 1.51% ± 0.18%, LPA = 2.18% ± 0.18% (p ≤ 0.01 re control), LPA+BIM-1 (10 μM) = 2.64% ± 0.18% (p ≤ 0.0008 re control, N.S. re LPA alone). (C) Shortening in untreated cells (n = 5) and cells exposed to BIM-1 (1 or 10 μM) only (n = 4): control = 1.51% ± 0.18%, BIM-1 (1 μM) = 1.02% ± 0.10%, BIM-1 (10 μM) = 0.64% ± 0.20% (p ≤ 0.02 and p ≤ 0.0001 re control, respectively, and p ≤ 0.01 between them).