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. 2015 May 5;108(9):2396–2407. doi: 10.1016/j.bpj.2015.03.033

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Snapshots of numerical simulations before and after symmetry breaking. (A) Symmetrical behavior before symmetry breaking changes to an asymmetrical shape and chemical patterning after symmetry breaking (C). (B) Sectional plane used for (A) and (C). (Open arrows) Direction of tissue motion; (purple color) high levels of activator morphogen Φ_A. Please note that there are moments of anisotropic inflation-deflation after symmetry breaking (lower panel, right-hand side). All simulations consider the OMC model of initial size r₀ = 138 μm. To see this figure in color, go online.