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. 2015 Mar 10;25(5):561–573. doi: 10.1038/cr.2015.30

Figure 1.

Figure 1

FBW7 is downregulated in pancreatic cancer. (A) Immunoblot analysis of the indicated human pancreatic cancer cell lines. The HPDE cell line was included as a positive control for the detection of endogenous FBW7 expression, and α-tubulin was used as a loading control. (B) IHC staining of human pancreatic adenocarcinoma tissue arrays using specific antibodies for FBW7. T, tumor; ANT, adjacent normal tissues; scale bar, 200 μm; magnification scale bar, 40 μm. (C) Kaplan-Meier analysis of overall survival rate of pancreatic cancer patients according to the expression of FBW7 (n = 86, P = 0.029, log-rank test).