Table 2. The amino acids recognized by the neutralizing antibodies and those confirmed to be involved in virus-host interactions.

mAb	Key aa of the epitope region	Method used to identify	Location of the epitope	Genotype	Reference
Based on mutation/truncation studies to test antibody binding
8C11	E479, Y485, D496, R512, K534, H577, R578	Crystal Structure combined with mutation assay	Groove region	1	17
8G12	E549,K554,G591	Crystal Structure combined with mutation assay	Dimerization region	1 & 4	this study
12A10	Linear epitope 423-438	Mutation assay	M domain	1	29
8H3	E479,Y485,I529, K534	Mutation assay	Groove region	1	11
MAB1323	S487, S488, T489, P491, N562,T564	Density fractionation assay	Dimerization region	3	9
MAB272	D496, T497, G591, P592	Density fractionation assay	Groove region	3	9
Fab224	E479,K534,Y485, I529	Mutation assay	Groove region	1	32
HEV#4 and HEV#31	Linear epitope 578-607	Truncation binding assay	Dimerization region and groove region	1	33
Based on cell binding assay
4 mAbs	T489, P491, Y561, N562, T564, T585, T586	Binding to host cell model assay	Dimerization region	3	9
8C11	T497, R512, H577, R578	Binding to host cell model assay	Groove region	1	17
8G12	E549, K554, G591	Binding to host cell model assay	Dimerization region	1 & 4	this study
12A10	D430 and L433	Binding to host cell model assay	M domain	1	this study