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. 2015 Apr 29;15:325. doi: 10.1186/s12885-015-1339-1

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© Liu et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Illustration of hairpin structure of artificial microRNAs and recombinant adenoviruses. A: DNA sequences of artificial miRNAs targeting DNA polymerases α, δ and ε were based on natural structure of human miR-30. The bolds were core sequences acquired from RNAi Codex. B: a) Recombinant adenovirus Ad/AFP-Casp-AFP-amiR containing two expression cassettes to express artificial microRNAs targeting DNA polymerase α, δ, ε and active recombinant Caspase3. b) Recombinant adenovirus Ad/AFP only containing AFP promoter used as control.