Table 4.
Current N-acetyl cysteine (NAC) in Obsessive Compulsive Disorders (OCD) and Obsessive Compulsive Related Disorders: Clinical Trials
| Study | Participants | Study design | Expected completion | NAC dose (mg) | Outcome measure | Status |
|---|---|---|---|---|---|---|
| Pittenger et al. (Yale University) NCT00539513 |
Treatment refractory OCD patients | 12 Week RDBPCT | NA | 3,000 | Y-BOCS, HAM-D | Terminated due to limited participants and funding |
| Bloch et al. (Yale University) NCT01172275 |
Pediatric OCD patients (8–17 years of age) | 12 Week RDBPCT | 2014 | 2,700 | CY-BOCS, DY-BOCS, CGI, PAERS | Currently recruiting |
| Shavitt et al. (University of Sao Paulo) NCT01555970 |
Treatment refractory OCD patients | 16 Week RDBPCT | 2016 | 3,000 | Y-BOCS, DY-BOCS, CGI-I, CGI-S, BDI, BAI | Currently recruiting |
| Sarris et al. (University of Melbourne) ACTRN12613000310763l |
Adult OCD patients | 16 Week RDBPCT | 2014 | 3,000 | Y-BOCS, CGI-S, CGI-I, HAM-A, MADRS | Currently recruiting |
| Grant et al. (University of Chicago) NCT01063348 |
Excoriation | 12 Week RDBPCT | 2014 | 3,000 | Y-BOCS modified for PSP, SP-SAS | Currently recruiting |
ACTRN, Australian New Zealand Clinical Trials Registry; BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory; CGI-I, Clinical Global Impression Scale-Improvement; CGI-S, Clinical Global Impression Scale-Severity; CY-BOCS, Children’s Yale Brown Obsessive Compulsive Scale; DY-BOCS, Dimensional Yale Brown Obsessive Compulsive Scale; HAM-A, Hamilton Anxiety Rating Scale; HAM-D, Hamilton Depression Scale; MADRS, Montgomery Asberg Depression Rating Scale; NA, not applicable; NCT, National Clinical Trial; PAERS, Pediatric Adverse Events Rating Scale; PSP, pathological skin picking; RDBPCT, randomised, double-blind, placebo controlled trial; SP-SAS, Skin Picking Symptom Assessment Scale; Y-BOCS, Yale Brown Obsessive Compulsive Scale.