Table 1.
Characteristics of sample by exposure to child abuse and its impact in adulthood
| Characteristic | Not exposed (n=13) | Exposed | NET rs2242226 | ||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Low impact (n=26) | High impact (n=12) | Pairwise differences* | CC/TC (n=30) | TT (n=21) | Pairwise differences* | ||
| Baseline HDRS | 25.9±5.7 | 24.0±3.9 | 21.5±3.4 | Low>High | 24.6±4.8 | 22.9±4.0 | – |
| Duration of depression (year) | 6.6±4.5 | 5.2±3.3 | 8.0±5.6 | – | 5.5±3.9 | 7.2±4.7 | – |
| Age (year) | 38.2±11.4 | 43.1±15.6 | 43.8±11.2 | – | 43.9±15.0 | 39.3±11.0 | – |
| Male | 23.1 (3) | 42.3 (11) | 41.7 (5) | – | 46.7 (14) | 23.8 (5) | – |
| Tertiary education | 53.8 (7) | 61.5 (16) | 25.0 (3) | Low>High | 56.7 (17) | 42.9 (9) | – |
| Employed | 100 (13) | 96.2 (25) | 100 (12) | – | 96.7 (29) | 100 (21) | – |
| Medication | |||||||
| Venlafaxine | 46.2 (6) | 42.3 (11) | 58.3 (7) | – | 46.7 (14) | 47.6 (10) | – |
| Escitalopram | 53.8 (7) | 57.7 (15) | 41.7 (5) | – | 53.3 (16) | 52.4 (11) | – |
| Venlafaxine dose at 8 weeks (mg) | 187.5±78.7 | 150.0±82.2 | 203.6±36.6 | – | 160.7±77.0 | 195.0±63.2 | – |
| Escitalopram dose at 8 weeks (mg) | 24.3 (7.7) | 22.7 (7.0) | 22.0 (10.9) | – | 23.1 (7.0) | 22.7 (9.0) | – |
| ABCB1 rs1045642-TT carrier | 30.8 (4) | 34.6 (9) | 25.0 (3) | – | 36.7 (11) | 23.8 (5) | – |
| CYP2C19 extensive metaboliser | 84.6 (11) | 65.4 (17) | 75.0 (9) | – | 70.0 (21) | 76.2 (16) | – |
| CYP2D6 extensive metaboliser | 61.5 (8) | 65.4 (17) | 66.7 (8) | – | 63.3 (19) | 66.7 (14) | – |
| 5HTTLPR l allele carrier | 84.6 (11) | 84.6 (22) | 83.3 (10) | – | 76.6 (23) | 85.7 (18) | – |
Values are presented as mean±standard deviation or percent (number).
*
Significant at p<0.05.