Table 3.
Comparisons of the discriminatory ability of prognostic scores by comparing the AUC
| Indexes | AUC | 95% CI | Pvalue | Significance of comparison §P’value |
|---|---|---|---|---|
| 6 months of follow-up | ||||
| TNM stage (AJCC, 7th) | 0.752 | 0.658 – 0.847 | <0.001* | 0.53 |
| CRP/Alb (continuous) | 0.706 | 0.597 – 0.815 | <0.001* | - |
| CRP/Alb (categorical) | 0.702 | 0.604 – 0.800 | <0.001* | - |
| mGPS | 0.665 | 0.550 – 0.781 | 0.003* | 0.61 |
| NLR (continuous) | 0.649 | 0.553 – 0.745 | 0.007* | 0.44 |
| NLR (categorical) | 0.584 | 0.484 – 0.683 | 0.132 | 0.09 |
| PLR (continuous) | 0.650 | 0.557 – 0.743 | 0.007* | 0.45 |
| PLR (categorical) | 0.563 | 0.450 – 0.677 | 0.255 | 0.07 |
| 1 year of follow-up | - | |||
| TNM stage (AJCC, 7th) | 0.706 | 0.642 – 0.771 | <0.001* | 0.87 |
| CRP/Alb (continuous) | 0.698 | 0.631 – 0.765 | <0.001* | - |
| CRP/Alb (categorical) | 0.670 | 0.600 – 0.739 | <0.001* | - |
| mGPS | 0.626 | 0.550 – 0.701 | 0.001* | 0.16 |
| NLR (continuous) | 0.576 | 0.506 – 0.645 | 0.040* | 0.01* |
| NLR (categorical) | 0.552 | 0.482 – 0.621 | 0.162 | 0.02* |
| PLR (continuous) | 0.584 | 0.509 – 0.659 | 0.022* | 0.03* |
| PLR (categorical) | 0.574 | 0.499 – 0.648 | 0.046* | 0.06 |
| 2 years of follow-up | ||||
| TNM stage (AJCC, 7th) | 0.731 | 0.680 – 0.783 | <0.001* | 0.02* |
| CRP/Alb (continuous) | 0.638 | 0.579 – 0.697 | <0.001* | - |
| CRP/Alb (categorical) | 0.619 | 0.560 – 0.679 | <0.001* | - |
| mGPS | 0.574 | 0.513 – 0.636 | 0.015* | 0.14 |
| NLR (continuous) | 0.555 | 0.496 – 0.614 | 0.074 | 0.05* |
| NLR (categorical) | 0.550 | 0.491 – 0.609 | 0.102 | 0.10 |
| PLR (continuous) | 0.566 | 0.506 – 0.626 | 0.031* | 0.09 |
| PLR (categorical) | 0.556 | 0.495 – 0.617 | 0.067 | 0.14 |
*Significant P value of ROC curves analysis.
Abbreviation: ROC receiver operating characteristics, AUC area under the curves, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio.
§ Comparisons of AUC values were made between the CRP/Alb ratio and other inflammation-based prognostic factors using z test method, a two tailed P value <0.05 was considered statistically significant. Significant differences were marked with “*”. Continuous indexes were compared with the CRP/Alb ratio as a continuous variable, while categorical indexes were compared with the CRP/Alb ratio as a categorical variable.