Table 2. Meta-analysis results of the 4 novel psoriasis susceptibility loci.
| Gene | SNP | Chr | BP.B37 | RA | RAF |
Stage | European |
Chinese |
Combined All |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EUR | CHN | P | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | PQ | ||||||
| TP63 | rs28512356 | 3 | 189615475 | C | 0.799 | 0.826 | GWAS | 9.99E−06 | 1.20 (1.11–1.30) | 9.52E−01 | 1.00 (0.88–1.13) | 7.70E−06 | 1.10 (1.06–1.15) | 9.62E−04 |
| Validation | 9.30E−04 | 1.15 (1.06–1.25) | 4.93E−01 | 1.03 (0.96–1.10) | ||||||||||
| Combined | 4.31E−08 | 1.17 (1.11–1.24) | 5.68E−01 | 1.02 (0.96–1.08) | ||||||||||
| COG6 | rs34394770 | 13 | 40333369 | T | 0.643 | 0.763 | GWAS | 5.55E−07 | 1.18 (1.11–1.26) | 1.22E−01 | 1.10 (0.98–1.23) | 4.87E−08 | 1.11 (1.07–1.15) | 2.04E−02 |
| Validation | 8.21E−03 | 1.12 (1.03–1.21) | 1.43E−01 | 1.05 (0.98–1.11) | ||||||||||
| Combined | 2.65E−08 | 1.16 (1.10–1.22) | 4.63E−02 | 1.06 (1.00–1.12) | ||||||||||
| LOC144817 | rs9533962 | 13 | 45334194 | C | 0.406 | 0.449 | GWAS | 1.76E−03 | 1.11 (1.04–1.18) | 3.93E−05 | 1.23 (1.12–1.36) | 7.53E−11 | 1.12 (1.08–1.15) | 2.91E−01 |
| Validation | 1.60E−06 | 1.16 (1.09–1.24) | 5.30E−02 | 1.06 (1.00–1.12) | ||||||||||
| Combined | 1.93E−08 | 1.14 (1.09–1.19) | 2.25E−04 | 1.09 (1.04–1.15) | ||||||||||
| RUNX1 | rs8128234 | 21 | 36470865 | T | 0.197 | 0.111 | GWAS | 1.82E−05 | 1.19 (1.10–1.28) | 8.98E−02 | 1.15 (0.98–1.34) | 5.99E−08 | 1.13 (1.08–1.18) | 4.23E−02 |
| Validation | 4.77E−04 | 1.15 (1.06–1.24) | 3.35E−01 | 1.04 (0.96–1.13) | ||||||||||
| Combined | 3.74E−08 | 1.17 (1.11–1.23) | 9.88E−02 | 1.06 (0.99–1.14) | ||||||||||
BP.B37, position based on NCBI build 37; CHN, Han Chinese samples; Chr, chromosome; GWAS, genome-wide association study; EUR, European samples; RA, risk alleles; RAF, risk allele's frequencies; OR, odds ratio; P: association P values in logistic regression test (alleles dosages in GWAS studies); 95% CI, 95% confidence interval; PQ: P values of heterogeneity test; SNP, single-nucleotide polymorphism.