Table 3. Histone H3 gene mutations and phenotypes of hst3Δ hst4Δ mutant cells.
| Histone mutant | Sensitivity at 37° | MMS sensitivity | HU sensitivity |
|---|---|---|---|
| hst3Δ hst4Δ | |||
| H3 WT | Ts- | S | S |
| H3 R2A | Ts- | S | S |
| H3 R2K | Ts- | S | S |
| H3 T6A | Ts- | S | S |
| H3 T6E | Ts- | S | S |
| H3 K9A | Ts- | S | S |
| H3 K9R | Ts- | S | S |
| H3 K9Q | Ts- | S | S |
| H3 S10A | Ts- | S | S |
| H3 S10E | Ts- | S | S |
| H3 T11A | Ts- | S | S |
| H3 T11E | Ts- | S | S |
| H3 K14A | Ts- | S | S |
| H3 K14R | Ts- | S | S |
| H3 K14Q | Ts- | S | S |
| H3 R17A | Ts- | S | S |
| H3 R17K | Ts- | S | S |
| H3 K18A | Ts- | S | S |
| H3 K18R | Ts- | S | S |
| H3 K18Q | Ts- | S | S |
| H3 K23A | Ts- | S | S |
| H3 K23R | Ts- | S | S |
| H3 K23Q | Ts- | S | S |
| H3 R26A | Ts- | S | S |
| H3 K26K | Ts- | S | S |
| H3 K27A | Ts- | S | S |
| H3 K27R | Ts- | S | S |
| H3 K27Q | Ts- | S | S |
| H3 WT | Ts- | S | S |
| H3 S28A | Ts- | S | S |
| H3 S28E | Ts- | S | S |
| H3 R52A | Ts- | S | S |
| H3 R52K | Ts- | S | S |
| H3 R52Q | Ts- | S | S |
| H3 R53A | Ts- | S | S |
| H3 R53K | Ts- | S | S |
| H3 R53Q | Ts- | S | S |
| H3 K56R | Tr | R | R |
| H3 K56Q | Tr | R | R |
| H3 K79A | Tr | R | R |
| H3K79R | Tr | R | R |
| H3 K91A | Ts- | S | S |
| H3 K91R | Ts- | S | S |
| H3 K91Q | Ts- | S | S |
| H3 K115A | Ts- | S | S |
| H3 K115R | Ts- | S | S |
| H3 K115Q | Ts- | S | S |
| H3 T118A | Ts- | S | S |
| H3 T118E | Ts- | S | S |
| H3 K122A | Ts- | S | S |
| H3 K122R | Ts- | S | S |
| H3 K122Q | Ts- | S | S |
Ts-, thermosensitive (fails to grow at 37°); Tr, thermoresistant (grows at 37°); S, growth compromised on plates containing either 0.01% MMS or 100 mM HU; R, histone gene mutations that rescue, at least partially, the MMS or HU sensitivity of hst3Δ hst4Δ cells.