Table 1.
Demographics
| Non-HIV-Infected Controls (n=41) | HIV-Infected Subjects (n=102) | P-value | |
|---|---|---|---|
| Demographics | |||
| Age, years | 45.0 (41.5, 50.5) | 48.0 (41.8, 52.0) | 0.18 |
| Race | 0.19 | ||
| White | 61 | 63 | |
| Black | 17 | 22 | |
| Hispanic | 7 | 12 | |
| Asian | 7 | 1 | |
| Native American | 5 | 3 | |
| Family history of premature heart disease, % | 13 | 22 | 0.24 |
| Current smoker, % | 29 | 41 | 0.20 |
| Diabetes mellitus, % | 2 | 7 | 0.26 |
| Use of antihypertensive medications, % | 8 | 29 | 0.003 |
| Use of lipid-lowering medications, % | 13 | 27 | 0.05 |
| Hepatitis C infection, %, self-reported | 2 | 25 | 0.0003 |
| Metabolic Parameters | |||
| Body mass index, kg/m2 | 26.3 (23.5, 29.6) | 25.7 (23.7, 29.1) | 0.75 |
| Systolic blood pressure, mm Hg | 117 (110, 124) | 120 (112, 127) | 0.22 |
| Total cholesterol level, mg/dL | 177 (154, 201) | 173 (155, 201) | 0.94 |
| LDL cholesterol level, mg/dL | 110 ± 33 | 101 ± 31 | 0.15 |
| HDL cholesterol level, mg/dL | 46 (41, 52) | 45 (38, 55) | 0.75 |
| Triglyceride level, mg/dL | 80 (64, 123) | 109 (81, 182) | 0.001 |
| Adiponectin level, ng/mL | 4362 (3326, 7106) | 5454 (2521, 10125) | 0.50 |
| HIV Disease-Related Parameters | |||
| Duration of HIV infection, years | N/A | 13.8 ± 6.5 | N/A |
| Currently receiving antiretroviral therapy, % | N/A | 95 | N/A |
| Duration of antiretroviral therapy, years | N/A | 7.9 (3.1, 11.0) | N/A |
| Current PI treatment, % | N/A | 52 | N/A |
| Current NRTI treatment, % | N/A | 92 | N/A |
| Current NNRTI treatment, % | N/A | 47 | N/A |
| Current CD4+ count, cells/mm3 | N/A | 473 (303, 748) | N/A |
| Nadir CD4 count, cells/mm3, self-reported | N/A | 175 (57, 278) | N/A |
| HIV RNA level (viral load), copies/mL | N/A | <50 (<50 to <50) | N/A |
| Undetectable viral load (<50 copies/mL), % | N/A | 81 | N/A |
| Immunologic/Inflammatory Parameters | |||
| High-sensitivity C-reactive protein (CRP), mg/L | 1.3 (0.7, 3.3) | 1.6 (0.7, 3.8) | 0.49 |
| High-sensitivity interleukin-6 (IL-6), pg/mL | 0.6 (0.5, 1.0) | 0.9 (0.7, 1.5) | 0.01 |
| D-dimer, ng/mL | <220 (<220, 333) | <220 (<220, 322) | 0.93 |
| Lipopolysacharide (LPS), ng/mL | 0.07 (0.06, 0.1) | 0.1 (0.07, 0.1) | 0.0004 |
| Soluble CD 14 (cSD14), ng/mL | 211 (121, 374) | 305 (157, 440) | 0.08 |
| Soluble CD163 (sCD163), ng/mL | 765 (572, 1054) | 1063 (695, 1577) | 0.0007 |
LDL = low density lipoprotein; HDL = high density lipoprotein; PI = protease inhibitor; NRTI = nucleoside reverse transcriptase inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor.