Figure 4.

Example query from the MIsoMine ‘Function’ and ‘Network’ pages. (A) Query the isoform-level function database using Calu (calumenin) as an example. While having the same number of amino acids, its two isoforms NM_007594.3 and NM_184053.2 are different in their exons. NM_184053.2 lacks the exon in NM_007594.3 (chr6:29,361,294-29,361,487) but contains an additional exon (chr6:29,361,560-29,361,753). The Pfam domains of the two isoforms are shown. The fold change of probabilities with respect to random predictions for the two isoforms to be annotated to a function (GO term) is displayed in the table. (B) Query the isoform-level functional relationship network database using Calu as an example. In this network, a node is an isoform and an edge indicates the probability that two isoforms work in the same biological process or pathway. This network contains the functional relationships of all possible mouse isoform pairs. The top linked isoforms for each query are displayed using the d3 software.