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. 2015 May 7;3:27. doi: 10.3389/fcell.2015.00027

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Copyright © 2015 Matsui, Ishikawa and Bessho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell dynamics during collective DFC migration. Depending on the formation of tight junction between DFC and EVL, directed migration of the DFC cluster toward the vegetal pole passively occurs (blue arrows). EVL, enveloping layer; DC, deep cells; YSL, yolk syncytial layer; DFC, dorsal forerunner cells. Time-lapse images from 0 to 16 min (4 min intervals) in the control Tg[sox17:GFP] embryo (left panels). Dorsal view, anterior to the top. Scale bar: 20 μm. As shown previously (Ablooglu et al., 2010), GFP-positive DFCs at the leading edge frequently generate filopodium (arrow) and lamellipodium (bracket) (right panels). These findings suggest that, in addition to the passive migration through the formation of DFC-EVL tight junction, DFCs have a potential to migrate toward the vegetal pole.