Table 5.
Proteins identified as more abundant in cholangiocarcinoma than in primary sclerosing cholangitis
| Proteins | Accession | MW (kDa) | Average SC |
NSAF ratio | P-value (t-test) | |
|---|---|---|---|---|---|---|
| CCA | PSC | |||||
| Serum albumin | 4502027 | 69 | 1338.0 | 334.5 | 2.16 | 0.03297 |
| Alpha-2-macroglobulin precursor | 66932947 | 163 | 173.0 | 29.5 | 3.28 | 0.03422 |
| Haptoglobin isoform 1 pre-pro-protein | 4826762 | 45 | 108.7 | 14.7 | 3.79 | 0.02149 |
| Complement C3 precursor | 115298678 | 187 | 269.7 | 31.7 | 4.32 | 0.04534 |
| Ceruloplasmin precursor | 4557485 | 122 | 55.7 | 6.5 | 5.14 | 0.01608 |
| Apolipoprotein A-I pre-pro-protein | 4557321 | 31 | 40.3 | 1.7 | 13.81 | 0.02004 |
| Carbonic anhydrase 1 | 192447430 | 29 | 29.7 | 0.7 | 15.31 | 0.00834 |
| Peroxiredoxin-2 isoform a | 32189392 | 22 | 29.7 | 0.8 | 18.27 | 0.00005 |
| Hemoglobin subunit alpha | 4504345 | 15 | 271.7 | 3.7 | 26.52 | 0.01789 |
| Apolipoprotein B-100 precursor | 105990532 | 516 | 127.7 | 0.0 | PSC only | 0.01591 |
| Hemoglobin subunit delta | 4504351 | 16 | 26.7 | 0.0 | PSC only | 0.00001 |
| Complement C4-B pre-pro-protein | 178557739 | 193 | 52.3 | 0.0 | PSC only | 0.02317 |
| Intercellular adhesion molecule 1 precursor | 167466198 | 58 | 4.7 | 0.0 | PSC only | 0.00097 |
| Peptidyl-prolyl cis-trans isomerase A | 10863927 | 18 | 5.7 | 0.0 | PSC only | 0.00309 |
MW = molecular weight; SC = spectral count; NSAF = normalized spectral abundance factor.