Table 1.
Anthropometric data, smoke exposure, pulmonary function, and presence of purulent sputum in 69 patients with COPD subdivided according to the predominant mechanism of air flow limitation and sex
| All patients (n=69) | Predominant airway phenotype (n=28) | Predominant emphysema phenotype (n=41) | P | Males (n=42) | Females (n=27) | P | |
|---|---|---|---|---|---|---|---|
| Age (years) | 67±9 | 66±8 | 66±10 | NS | 67±9 | 66±9 | NS |
| BMI (kg/m2) | 25±4 | 27±4 | 24±4 | <0.01 | 25±4 | 25±4 | NS |
| Packs/year | 42±23 | 35±24 | 47±22 | <0.05 | 41±18 | 44±30 | NS |
| FEV1% | 61±27 | 73±23 | 53±26 | <0.001 | 54±25 | 73±25 | <0.01 |
| FRC% | 126±31 | 111±25 | 137±30 | <0.001 | 131±33 | 120±24 | NS |
| DLCO% | 69±22 | 85±18 | 57±16 | <0.0001 | 67±22 | 69±21 | NS |
| Presence of purulent sputum | 16/69 | 12/28 | 4/41 | <0.01 | 11/42 | 5/27 | NS |
Notes: Data are mean ± SD for continuous variables and proportion for categorical values. Sputum purulence (entered as 1 when present and 0 when absent in the regression equation employed to phenotype patients with COPD). Packs/year is the mean number of daily cigarettes × number of years/20.
Abbreviations: BMI, body mass index (weight/height2); COPD, chronic obstructive pulmonary disease; DLCO%, lung diffusing capacity for carbon monoxide (% of predicted); FEV1%, forced expiratory volume in one second (% of predicted); FRC%, functional residual capacity (% of predicted); NS, not significant; SD, standard deviation.