Fig. 4.

Power under different critical values of the P values obtained using the Wald test for the case–control simulation data-set under scenario 1 when positive interaction effects present. For each graph, Greek symbols and solid lines correspond to the NOIA method, and the broken line corresponds to the functional method. The upper panel is for the additive effects and dominant effects of locus A and locus B, respectively. The bottom panel is for the interaction effect between locus A and locus B. The simulating values of the genetic effects were ${\overrightarrow{E}}_{\mathrm{F}}^{\mathrm{T}}[R,a_A,d_A,a_B,d_B,aa,ad,da,dd]=[-2.00,0.50,0.30,0.40,0.37,0.15,0.08,0.10,0.04]$. Corresponding values of the statistical genetic effects were ${\overrightarrow{E}}_{\mathrm{S}}^{\mathrm{T}}=[-1.07,0.78,0.36,0.70,0.45,0.23,0.10,0.12,0.04]$