Table 3. P values for the main effects and interaction effects when rs1129038 are used for reference SNP in the two-locus association analysis by NOIA statistical model (P < 10⁻⁶).

CHR	SNP	Coordinate	Gene symbol	P value
				Add_A	Dom_A	Add_B	Dom_B	Add-Add	Dom-Add	Add-Dom	Dom-Dom
5	rs6871296	55175024	LOC402216	0.07	0.02	5.78E–08	0.46	0.45	1.06 × 10−7	0.90	0.91
5	rs3857290	55182187	Il31RA	0.08	0.03	6.26e–08	0.45	0.45	2.57 × 10−7	0.87	0.83
5	rs6876491	55181692	Il31RA	0.04	0.02	4.19e–08	0.33	0.47	5.73 × 10−7	0.86	0.92
5	rs10042075	55178483	Il31RA	0.03	0.01	3.01e–08	0.35	0.51	6.03 × 10−7	0.86	0.73
5	rs327240	55216666	Il31RA	0.02	0.25	2.61e–08	0.34	0.61	1.20 × 10−6	0.75	0.27
5	rs3843458	55090435	DDX4	0.03	0.12	6.69e–08	0.26	0.46	2.60 × 10−6	0.70	0.60
5	rs957459	55118231	DDX4	0.07	0.05	6.65e–08	0.28	0.46	2.92 × 10−6	1.00	0.36
5	rs10035707	55098280	DDX4	0.06	0.05	6.43e–08	0.28	0.46	4.07 × 10−6	0.99	0.33
10	rs12775320	78584174	KCNMA1	0.61	0.42	1.95e–07	0.00	0.50	6.58 × 10−6	0.78	0.51
4	rs6825100	17305532	KIAA1276	0.27	0.10	7.30e–08	0.15	0.49	9.49 × 10−6	0.04	0.28

Locus B is the reference SNP, rs1129038; locus A is the candidate interacted SNP that scanned from the whole genome

Add additive effect, Dom dominant effect, Add-Add additive–additive interaction effect, Dom-Add dominant–additive interaction effect, Add-Dom additive–dominant interaction effect, Dom-Dom dominant–dominant interaction effect