Table 1.
The reported stem cell-based therapies in AD animal models
| Donor cells | AD models | Graft site | Behavior recovery | Possible mechanism | Key refs. |
|---|---|---|---|---|---|
| Mouse astrocytes | ApdE9 transgeneic mouse | Hippocampus | Not known | Aβ deposits clearing | [9] |
| Mouse adult NSCs | 3xTg transgeneic mouse | Hippocampus | Learning and memory | BDNF induction | [5] |
| Mouse cholinergic motor neuron precursors | Rat with NBM lesion | NBM | memory recovery | Not Known | [6] |
| Human UCB-MSCs | Not known | Hippocampus | Memory | Reducing neuronal apoptosis | [7] |
| Mouse BM-MSCs | APP/PS1 transgeneic mouse | Hippocampus | Memory | reducing Aβ deposits | ([8] |
| Human iPSC-derived motor neuron precursors | PDAPP transgeneic mouse | Hippocampus | Spatial Memory | Not Known | [12] |
NSCs, neural stem cells, NBM, nucleus basalis of Meynert, UCB-MSCs, umbilical cord blood-derived mesenchymal stem cells, BM-MSCs, bone marrow-derived mesenchymal stem cells, PDAPP, PDGF promoter driven amyloid precursor protein transgenic mice.