TABLE 3.
Summary of 21 Cancers Identified in 21 Study Participants at 365 Days After Study Entry
| Histopathologic Finding | Tumor Size (cm) | Tumor Grade | TNM Category | Age (y) | Menopausal Status | Breast Density |
|---|---|---|---|---|---|---|
|
| ||||||
| Cancers found on MBI only (n = 14) | ||||||
| IDC | 4.1 | 2 | T2N2M0 | 54 | Premenopausal | Scattered fibroglandular densities |
| ILC | 3.6 | 2 | T2N1M0 | 67 | Postmenopausal | Extremely dense |
| IDC multifocal | 2.0 | 1 | T1cN0M0 | 77 | Postmenopausal | Heterogeneously dense |
| IDC | 1.9 | 2 | T1cN0M0 | 65 | Postmenopausal | Heterogeneously dense |
| IDCa | 1.4 | 1 | T1cN0M0 | 63 | Postmenopausal | Scattered fibroglandular densities |
| IDC | 0.9 | 2 | T1aN0M0 | 64 | Postmenopausal | Heterogeneously dense |
| IDCb | 0.9 | 1 | T1bN0M0 | 70 | Postmenopausal | Heterogeneously dense |
| IDC | 0.8 | 1 | T1bN0M0 | 81 | Postmenopausal | Heterogeneously dense |
| IDC multifocal | 0.7 | 3 | T1bN0M0 | 75 | Postmenopausal | Scattered fibroglandular densities |
| ILC | 0.5 | 1 | T1bN0M0 | 73 | Postmenopausal | Heterogeneously dense |
| IDC | 0.5 | 1 | T1aN0M0 | 70 | Postmenopausal | Heterogeneously dense |
| DCIS | 1.6 | Intermediate grade | T1s (DCIS) | 71 | Postmenopausal | Heterogeneously dense |
| DCIS | 0.6 | Intermediate grade | Tis (DCIS) | 64 | Postmenopausal | Heterogeneously dense |
| DCIS multifocal | 0.4 | Low grade | Tis (DCIS) | 49 | Premenopausal | Extremely dense |
| Cancers found on mammography only (n = 2) | ||||||
| IDC | 0.3 | 2 | T1aN0M0 | 49 | Premenopausal | Heterogeneously dense |
| DCIS | 0.5 | Intermediate grade | Tis (DCIS) | 62 | Postmenopausal | Heterogeneously dense |
| Cancers found on both MBI and mammography (n = 3) | ||||||
| IDC | 2.2 | 3 | T2N0M0 | 64 | Postmenopausal | Heterogeneously dense |
| IDC multifocal | 1.6 | 1 | T1cN1M0 | 53 | Perimenopausal | Extremely dense |
| DCIS with microinvasion | 2.0 | High grade | Tis (DCIS) | 74 | Postmenopausal | Heterogeneously dense |
| Cancers found on neither MBI nor mammography | ||||||
| (interval cancers) (n = 2) | ||||||
| ILC multifocal | 0.7 | 1 | T1bN0M0 | 45 | Premenopausal | Extremely dense |
| ILC multifocal | 0.6 | 1 | T1bN0M0 | 69 | Postmenopausal | Heterogeneously dense |
Note—MBI = molecular breast imaging, IDC = invasive ductal carcinoma, ILC = invasive lobular carcinoma in situ, DCIS = ductal carcinoma in situ.
a
In addition to the invasive cancer detected only on MBI, a mammographically occult 5.0-cm high-grade DCIS was detected by MBI in the contralateral breast.
b
In addition to the invasive cancer detected only on MBI, a mammographically occult 0.8-cm low-grade DCIS was detected by MBI in the contralateral breast.