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Redox regulation impairs Pin1 subcellular localization.
A and B) H2O2 treatment reduces Pin1 nuclear localization and increases cytoplasmic localization. WT or Pin1 KO cells or mouse brain tissues were immunostained with anti-Pin1 (green), anti-oxyPin1 (red) antibodies and DAPI (blue).
C) H2O2 treatment reduces Pin1 nuclear localization. WT or Pin1 KO cells were harvested and nuclear/cytoplasm fractions isolated, followed by detecting Pin1 protein using anti-Pin1 antibodies.
