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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Autophagy. 2010 Jul 1;6(5):614–621. doi: 10.4161/auto.6.5.12189

Figure 7.

Figure 7

Proposed model of the function of Keap1 in oxidative stress response and autophagy. In the unstressed cells, Keap1 sequesters Nrf2 in the cytosol. Keap1 is oxidized by reactive oxygen species (ROS), and Keap1 oxidation leads to Nrf2 dissociation. Nrf2 translocates to the nucleus and activates antioxidant response element (ARE)-containing genes. ROS also promotes the formation of Keap1-p62-LC3 complex that delivers ubiquitinated protein aggregates to the forming autophagosomes (phagophore).