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Effect of bundled goal-directed therapy (GDT) on the odds ratio of survival (95% confidence interval (CI)) for the 18 observational trials analyzed. All 18 studies: odds ratio, 0.580; 95% CI 0.501 to 0.672; P < 0.0001 (I 2 = 32%, P = 0.091). With the Ferrer study [33] removed: odds ratio 0.561; 95% CI 0.499 to 0.631; P < 0.0001 (I 2 = 0%, P = 0.796).
