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F192L/M495V human FAAH mutant confers sensitivity to inhibition by CBD. A, [14C]AEA hydrolysis in homogenates of rat or mutant FAAH-transfected cells in the presence or absence of 100 μm CBD. B, CBD inhibitor sensitivity profile in homogenates of human, rat, or F192L/M495V hFAAH-transfected cells. Data represent the mean ± S.E. for 3 replicates per group. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus vehicle control.
