TABLE 2.
Binding affinities of THC, CBD, AEA, 2-arachidonoylglycerol (2-AG), and oleic acid (OA) to human FABPs
The Ki values were determined by NBD-stearate fluorescence displacement assays as described under “Experimental Procedures.” Values are averages ± S.E. of at least three independent experiments.
| Compound | Ki |
||
|---|---|---|---|
| FABP3 | FABP5 | FABP7 | |
| μm | |||
| CBD | 1.69 ± 0.20 | 1.88 ± 0.10 | 1.52 ± 0.39 |
| THC | 1.98 ± 0.36 | 3.14 ± 0.26 | 1.04 ± 0.13 |
| AEA | 3.07 ± 0.28 | 1.26 ± 0.18 | 0.80 ± 0.06 |
| 2-AG | 1.65 ± 0.22 | 1.45 ± 0.21 | 0.20 ± 0.03 |
| OA | 0.04 ± 0.00 | 0.56 ± 0.14 | 0.04 ± 0.00 |