TABLE 1.
Exposure to high CO2 causes normoxic hypercapnia
C57Bl/6 mice were exposed to control conditions at room air (CT, n = 7) or high CO2/hypercapnia for different time points (HC-3 days, n = 6; HC-5 days, n = 3; HC-7 days, n = 3). Samples were analyzed with a pHOx Plus Blood Gas Analyzer, as described under “Experimental Procedures.”
| Variable | Arterial blood gases |
p Value | |||
|---|---|---|---|---|---|
| CT | HC-3 days | HC-5 days | HC-7 days | ||
| paCO2 (mm Hg) | 33 ± 5.1 | 75 ± 6.8 | 79 ± 4.6 | 79 ± 1.8 | p < 0.0001 |
| paO2 (mm Hg) | 89 ± 6.1 | 109 ± 7.8 | 103 ± 11 | 111 ± 1.1 | p < 0.05 |
| pH | 7.42 ± 0.04 | 7.29 ± 0.05 | 7.3 ± 0.02 | 7.32 ± 0.02 | p < 0.05 |
| HCO3− (mmol/liter) | 22 ± 4.1 | 37 ± 2.7 | 42 ± 1.2 | 41 ± 2.7 | p < 0.01 |