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A–C, normalized transretinal M-cone responses to flashes bleaching 0.0004% (A), 0.034% (B), and 3.6% (C) of visual pigments per cone. Traces colored in black, red, and blue in each panel represent control, GRK1+, and GRK1+/− retinas, respectively. D, integration time as a function of the fraction of bleached visual pigments per cone (%). Integration time is defined as the area under the normalized photoresponse. Error bars show S.E.
