FIGURE 8.

Effect of Ca_v1.2_33L channels on the gating properties of the reference Ca_v1.2 channels when transfected at 1:1 ratio. A, sample traces from the recordings for the tail currents and steady-state inactivation. B, plots of steady-state inactivation (f_∞) and activation (d_∞) curves of the reference cardiac Ca_v1.2 channels co-expressed with Ca_v1.2_33L (●) and pcDNA3 vector (○). Ca_v1.2_33L channels slightly shifts activation and SSI curves of the reference channels toward negative potential. All recordings were performed in 1.5 mm Ca²⁺ bath solution. The protocols and fittings were described under “Materials and Methods.”