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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Neuropharmacology. 2010 Jan 6;58(7):972–980. doi: 10.1016/j.neuropharm.2009.12.017

Figure 3. Representation of energetically favorable rtPA/PAI-1 derived peptide-peptide complexes.

Figure 3

The peptides adopt an extended conformation upon binding to the previously described PAI-docking site in tPA. Most of the hydrophobic residues of the 18-aa peptide are buried within the hydrophobic surface regions of the enzyme.