Fig. 2.
a Influence of cerebral hypoxia/ischemia (H/I) on pial artery diameter in the absence of endothelin-1 (ET-1). Influence of ET-1 (10−10, 10−8 M) on pial artery diameter in newborn pigs before (control), after H/I, or H/I treated with EEIIMD (PAI-1-derived peptide), EEIIMR (inactive analog), or U 0126 (ERK MAPK antagonist) (all 1 mg/kg iv), n = 5, b pretreatment 30 min before H/I, c post-treatment 60 min after H/I. Baseline pial artery diameters were 139 ± 14, 120 ± 11, 117 ± 10, 120 ± 13, and 115 ± 11 µm for control, H/I, H/I + EEIIMR, H/I + EEIIMD, and H/I + U 0126 treated, respectively. The new baseline diameter was used to calculate percent changes in diameter after H/I. *p < 0.05 versus corresponding control value +p < 0.05 versus corresponding non-treated H/I value