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. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Mol Genet Metab. 2014 Nov 9;114(2):248–258. doi: 10.1016/j.ymgme.2014.11.004

A.

Light microscopy of an endomyocardial biopsy taken from the right ventricle of a 56-year-old man hemizygous for the GLA p.(Arg118Cys) sequence variant. None of the typical features of Fabry disease cardiomyopathy – e.g. cardiomyocyte hypertrophy or vacuolation, enlarged nuclei or fiber branching and disarray –, are observed in this section.

B.

An electron microphotograph of the endomyocardial biopsy of the same patient also does not show any cardiomyocyte inclusions typical of Fabry disease, i.e. with the ultrastructural morphology of “zebra body” or “myelin figure”.

A.

Light microscopy of an endomyocardial biopsy taken from the right ventricle of a 56-year-old man hemizygous for the GLA p.(Arg118Cys) sequence variant. None of the typical features of Fabry disease cardiomyopathy – e.g. cardiomyocyte hypertrophy or vacuolation, enlarged nuclei or fiber branching and disarray –, are observed in this section.

B.

An electron microphotograph of the endomyocardial biopsy of the same patient also does not show any cardiomyocyte inclusions typical of Fabry disease, i.e. with the ultrastructural morphology of “zebra body” or “myelin figure”.