Table 1. Toxicity of ciprofloxacin derivatives in mice.

Compound dose (mg/kg)	Mouse weight (g)		Serum urea a	Serum creatinine kinase b
	Initial	After 48 h
Vehicle	20.15	21.28	53.0	ND
Et-Cipro 25	19.87	22.25	55.8	1727
50	19.15	20.92	51.2	182
100	20.71	22.27	55.1	578
200	20.0	22.17	49.3	583
Vehicle	19.30	21.91	48.0	420
Adam-Cipro 25	20.65	23.10	ND	ND
50	20.80	22.12	ND	ND
100	20.45	23.50	ND	ND
200	21.11	23.28	51.5	467
Vehicle	19.49	22.94	46.7	563
Ph-Cipro 25	21.21	23.85	49.2	ND
50	19.30	22.72	50.6	506
100	19.21	21.94	52.8	ND
200	19.93	22.20	46.2	1541

Swiss mice were administrated with a single oral dose of different ciprofloxacin derivatives, and monitored for 48h.

Serum levels of urea and creatinine kinase were measured in blood samples harvested 40h after drug administration. The following reference values (mg/kg) were used:

^a18–29 mg/dL

^b, ≤ 1070 U/L.