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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2014 Sep 3;3(6):465–487. doi: 10.1002/wdev.152

Figure 3. Structure of polycystins.

Figure 3

Polycystin-1 has a large extracellular domain, 11 transmembrane domain and a short cytoplasmic tail. The coiled coil domain in the C-terminal end of PC-1 interacts with the C-terminal tail of Polycystin-2. Polycystin-2 has cytoplasmic N and C-terminus. Together, PC1 and PC2 mediate calcium entry into cells. (Modified from 2)