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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Nature. 2014 Jul 16;512(7512):49–53. doi: 10.1038/nature13527

Figure 1. Overall structure of the DDB1-CRBN complex.

Figure 1

(a) Cartoon representation of the hsDDB1-ggCRBN-thaliomide structure: DDB1 highlighting domains BPA (red), BPB (magenta), BPC (orange) and DDB1-CTD (grey); ggCRBN highlighting domains NTD (blue), HBD (cyan) and CTD (green). The Zn2+-ion is drawn as a grey sphere. (b) As in (a) with the thalidomide shown as yellow sticks. A close-up showing that all IMiDs occupy a common binding site on CRBN, and a close-up of the overall ggCRBN-CTD architecture. (c) ggCRBN-HBD helices and their interactions with DDB1.