Skip to main content
. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Nature. 2014 Jul 16;512(7512):49–53. doi: 10.1038/nature13527

Figure 2. Thalidomide binding to CRBN.

Figure 2

(a) Chemical structure of lenalidomide and (b) pomalidomide. (c) Sketch of thalidomide and its interactions with ggCRBN. (d) IMiDs are anchored through the glutarimide functionality hydrogen-bonding to ggCRBN His380 and Trp382 and the aliphatic face of the glutarimide engulfed in a hydrophobic cage. (e) Surface representation of ggCRBN (grey) and (S)-lenalidomide shown as yellow sticks, together with its positive mFo-DFc electron density (σ=3.5) shown in green. The fit of the (S)- and (R)-enantiomers is indicated.