Table 3. Association of 7 SNP loci with type 2 diabetes in a Japanese population.
| SNP | Nearby gene a | Risk Allele b | RAF (case/control) | Unadjusted | Adjusted c | ||
|---|---|---|---|---|---|---|---|
| p value | OR(95%CI) | p value | OR (95%CI) | ||||
| rs12571751 | ZMIZ1 | A | 0.55/0.53 | 2.7 × 10–3 | 1.114(1.038–1.195) | 4.1 × 10–3 | 1.123 (1.037–1.215) |
| rs10842994 | KLHDC5 | C | 0.83/0.82 | 0.046 | 1.096 (1.002–1.199) | 0.028 | 1.120 (1.013–1.238) |
| rs2796441 | TLE1 | G | 0.39/0.37 | 0.043 | 1.077 (1.002–1.157) | 0.052 | 1.083 (0.999–1.173) |
| rs459193 | ANKRD5 | G | 0.49/0.47 | 0.021 | 1.085 (1.012–1.163) | 0.084 | 1.071 (0.991–1.157) |
| rs10401969 | CILP2 | C | 0.100/0.099 | 0.884 | 1.009 (0.900–1.130) | 0.719 | 1.024 (0.900–1.164) |
| rs12970134 | MC4R | A | 0.170/0.168 | 0.235 | 1.058 (0.964–1.161) | 0.844 | 1.011 (0.911–1.121) |
| rs7202877 | BCAR1 | T | 0.790/0.786 | 0.614 | 1.022 (0.940–1.111) | 0.548 | 1.029 (0.937–1.130) |
| GRS-7 d , f | 3.0 × 10–5 | 1.071 (1.037–1.106) | 2.3 × 10–4 | 1.070 (1.032–1.109) | |||
| GRS-6 e , f | 1.6 × 10–3 | 1.059 (1.022–1.098) | 7.9 × 10–3 | 1.056 (1.014–1.099) | |||
The results of logistic regression analysis are shown.
a Information in the original report is shown.
b Risk allele reported in the previous reports.
c Adjusted for age, sex and BMI.
d The genetic risk score (GRS-7) was calculated according to the number of risk alleles by counting the 7 European genome-wide association study derived SNPs.
e The genetic risk score (GRS-6) was calculated according to the number of risk alleles by counting the 6 European genome-wide association study derived SNPs, rs10842994, rs2796441, rs459193, rs10401969, rs12970134, rs7202877
f Individuals who had complete genotype data for the 7 SNPs were used for the analyses (n = 6,200)