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. 2015 May 7;10(5):e0124302. doi: 10.1371/journal.pone.0124302

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© 2015 Balaji et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — A) Rate of metabolism, B) apoptosis, C) migration and D) invasion were compared between AFB, AFB+IL-10, and FFB to determine if IL-10 treatment can recapitulate the fetal functional profile in the FFB. IL-10 treatment recapitulated the migration and invasion aspects of the fetal-type fibroblast phenotype in AFB, but metabolism and apoptosis rates were not impacted by IL-10. Bar plots represent average±SD. Asterisks denote statistically significant differences between the groups (* p<0.05, ** p<0.01; Student’s t-test and ANOVA; n = 3 per group at similar passage number; each experiment was conducted in triplicates with cells from independent isolations).