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. 2015 May 7;10(5):e0124655. doi: 10.1371/journal.pone.0124655

Fig 7. Family 2A with a C3-p.I1157T mutation.

Fig 7

(A) Patient 2A1 (male) had six bouts of atypical hemolytic uremic syndrome (aHUS), at the age of 9, 15, 18, 22 and 29 (twice). Gray squares or circle indicate individuals who were not analyzed in this study. (B) The hemolytic assay showed that neither patient (P) nor his parents (father: F and mother: M) had appreciable hemolysis. However, Patient 2A1 and his father carried the same predisposing mutation p.I1157T in C3, confirmed by restriction fragment length polymorphism (RFLP) analysis (C) and direct DNA sequencing.