Table 2. Incidence of CHIKV infections and seroprevalence of CHIKV PRNT in different age groups. a .
Age | Subjects, n | CHIKV PRNT ≥10, n (% of age group) b | Symptomatic CHIKV infection, n [n/100 person-yrs (95% CI)] | Subclinical CHIKV infection, n [n/100 person-yrs (95% CI)] | Total CHIKV infection, n [n/100 person-yrs (95% CI)] | Ratio of subclinical to symptomatic CHIKV infection |
---|---|---|---|---|---|---|
6 mos—5 yrs | 148 | 1 (0.7) | 5 [3.23 (1.23, 7.08)] | 10 [6.46 (3.32, 11.47)] | 15 [9.69 (5.66, 15.59)] | 2:1 |
6–15 yrs | 184 | 2 (1.1) | 8 [4.23 (1.99, 7.98)] | 24 [12.68 (8.33, 18.55)] | 32 [16.91 (11.78, 23.56)] | 3:1 |
16–30 yrs | 168 | 34 (20.2) | 2 [1.13 (0.23, 3.63)] | 20 [11.32 (7.13, 17.14)] | 22 [12.45 (8.02, 18.51)] | 10:1 |
31–50 yrs | 170 | 90 (52.9) | 3 [1.8 (0.50, 4.81)] | 21 [12.63 (8.05, 18.94)] | 24 [14.43 (9.49, 21.12)] | 7:1 |
>50 yrs | 183 | 112 (61.2) | 1 [0.55 (0.05, 2.59)] | 12 [6.66 (3.64, 11.28)] | 13 [7.21 (4.04, 11.98)] | 12:1 |
All ages | 853 | 239 (28.0) | 19 [2.19 (1.36, 3.35)] | 87 [10.03 (8.09, 12.31)] | 106 [12.22 (10.06, 14.72)] | 4.6:1 |
aBased on 853 subjects with both enrollment and 12-month blood collections.
bCHIKV PRNT titer at enrollment using 80% plaque reduction.
CHIKV = chikungunya virus; n = number; CI = confidence interval; PRNT = plaque reduction neutralization test.