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. 2015 May 7;10(5):e0125343. doi: 10.1371/journal.pone.0125343

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© 2015 Kuo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 7 — (A) ALDH activity, (B) SP proportion and (C) CD133-ALDH double positivity is suppressed in JARID1B-shRNA infected cells, compared to JARID1B-expressing control cells. (D) Higher JARID1B expression is associated with poor prognosis in NB patients. A web-based software package, R2: microarray analysis and visualization platform (http://r2.amc.nl), consisting of 88 NB tumors with age, INSS staging, MYCN status, and survival information was used for this analysis. JARID1B expression is associated with more advanced tumor stage (stage 4 vs. stage 3, p = 7.6x10^-5). Using median mRNA level of JARID1B as the cutoff, the relapse-free survival probability of patients with higher JARID1B expression was significantly worse than those with lower expression (p = 0.027).