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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nat Struct Mol Biol. 2015 Apr 6;22(5):396–403. doi: 10.1038/nsmb.3000

Figure 3. The promoter-proximal response to P-TEFb inhibitors varies.

Figure 3

(a,b) Distribution of log2 of the ratio between treated and control samples for normalised read density in the first 5kb of the gene body (a) and in the TSS-proximal peak (b). * values in (a) indicate the proportion of genes with no reads in the 5kb body. (c) GRO-seq profile of EIF2S3. (d) Top, gene schematic of EIF2S3. Bottom, qRT-PCR analysis of pol II and Ser2P ChIP performed on HeLa cells untreated (Cont.) or treated with 100 μM KM or DRB. Error bars, s.e.m. (n = 3 biological replicates). (e) GRO-seq profile of CDKN1B, RPS14, RPS19 and DUSP1.