. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Pediatr Crit Care Med. 2015 May;16(4):366–374. doi: 10.1097/PCC.0000000000000351

Table 2.

Impact of Timing of Initiation of Therapeutic Plasma Exchange on Organ Failure Index, Vasoactive-Inotropic Score, and Extracorporeal Life Support Requirement.

		Early Group (n=6)	Late Group (n=8)	p value
Hours to TPE from Admission	All	16.5 ± 10.7	97.3 ± 54.6	0.004
Change in OFI	All	−1.7 ± 1.2	− 0.9 ± 0.6	0.14
Change in OFI	Survivors Only	− 2.3 ± 1.0	− 0.8 ± 0.8	0.03
Change in VIS	All	− 67.5 (28.0–171.2)	− 12.0 (7.2–18.5)	0.02
Change in VIS	Survivors Only	− 42.0 (16.0–76.3)	− 12.0 (5.3–29.0)	0.17
Hours Spent on ECLS After TPE	All	172.5 ± 169.6	248.0 ± 197.9	0.47
Hours Spent on ECLS After TPE	Survivors Only	133.3 ± 72.8	214.0 ± 208.2	0.48

TPE = therapeutic plasma exchange; OFI = Organ Failure Index; VIS = Vasoactive-Inotropic Score; ECLS = extracorporeal life support

Early group = patients receiving TPE within 30 hours from the time of PICU admission

Late group = patients receiving TPE after 30 hours from the time of PICU admission