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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nat Struct Mol Biol. 2015 Mar 30;22(5):425–431. doi: 10.1038/nsmb.2998

Figure 6. Fitting of the composite H. sapiens Y-complex into the cryo-ET map of the entire NPC.

Figure 6

(a) Consensus map calculated from the cryo-ET map of the human NPC (EMD code: 2444)15. The cytoplasmic ring density is highlighted in grey for clarity. (b) The top scoring fit of the composite H. sapiens Y-complex (conformation 1) and the second top scoring fit (conformation 2) are depicted. (c) A superposition of the two fits from (b) shows that they are related by a ~20° rotation about the Y-complex hub, and substantial bending of the long stack.