Figure 1.

Frailty and function.⁹¹ The dashed line above the shading represents the cut-point between function and frailty. The dashed line with arrow represents decline in physiologic reserve with typical aging. The solid line with arrow represents potential decline in physiologic reserve among childhood cancer survivors whose acute insult occurs early in life. The solid line with arrow pointing directly down represents the potential impact of lifestyle on the trajectory of physiologic capacity; the additional arrows pointing upward potential recovery from loss of function based on access to intervention.