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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Trends Mol Med. 2015 Mar 20;21(5):319–329. doi: 10.1016/j.molmed.2015.02.004

Table 1.

Summary of the biological properties of human FcγRs and IgG subclassesa.

Name FcγRI, CD64 FcγRIIa, CD32a FcγRIIb, CD32b FcγRIIIa, CD16a FcγRIIIb, CD16b
Expression Mono, Mac, Activated PMN Mono, Mac, PMN, DC, platelets All immune cells except T and NK APCs (mono, DC, B), NK cells PMN, some mono
Activating or Inhibitory Act Act Inh Act Act
Polymorphism None Known R131 H131 I232T F158 V158 NA1/NA2
Affinity for:
IgG1 ++++ + ++ ± + + ±
IgG2 − + + − − − −
IgG3 ++++ + + ± ++ +++ +
IgG4 +++ + + ± ± ± −
Murine Counterpart FcγRI FcγRIII FcγRIIb FcγRIV

Adapted from [33] and [75].

a

Abbreviations: APC, antigen presenting cell; DC, dendritic cell; Mac, macrophage; Mono, monocyte; NK, natural killer cell; PMN, polymorphonuclear leukocyte.