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Effect of acute administration of the Sig-1R antagonist BD-1063 (0, 3, 10, 30 mg/kg) on an operant second-order schedule of reinforcement to assess alcohol-seeking behavior in Scr:sP rats (n=7). The number of active lever presses following BD-1063 administration is shown in panel A, the number of lever presses on the inactive lever in panel B. Data represent Mean ± SEM; ** p < 0.01, *** p < 0.001 vs. vehicle-treated group.
