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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Epilepsy Behav. 2015 Mar 13;45:1–7. doi: 10.1016/j.yebeh.2015.02.013

Fig. 4. Fluoxetine but not doxapram or PK-THPP reduced the incidence of S-IRA in awake DBA/1 mice.

Fig. 4

Effect of systemic administration (i.p.) of fluoxetine (30 mg/kg), doxapram (50 mg/kg) and PK-THPP (10 mg/kg) on S-IRA in DBA/1 mice. Fluoxetine significantly decreased the incidence of S-IRA 30 min after injection (p<0.01, n = 10) as compared with vehicle control (n = 9). Doxapram (n = 8) and PK-THPP (n = 8) did not show any effect on the incidence of S-IRA 15 min after injection as compared with corresponding vehicle controls (n = 6–7). The blank bars indicate the incidence of S-IRA with vehicle injections, and the filled bars indicate that with drug injections. ** p<0.01: significantly different from vehicle control.