Table 3. Summary of statistically significant associations between biomarkers and MRS metabolites.
Positive associations are denoted by up arrow (↑) while negative associations are denoted by down arrow (↓). (1 = plasma models, 2 = CSF models, 3 = combined CSF and plasma models).
Underlined associations became statistically non-significant when baseline demographic and disease characteristics were included in the models.
| Frontal White Matter | Basal Ganglia | Mid Frontal Cortex | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Biomarker | Fluid | NAA/Cr | Cho/Cr | Glx/Cr | NAA/Cr | Cho/Cr | Glx/Cr | NAA/Cr | Cho/Cr | Glx/Cr |
| FKN | CSF | ↑(2) | ||||||||
| Plasma | ↑(3) | |||||||||
|
| ||||||||||
| IP-10 | CSF | ↓(2) | ||||||||
| Plasma | ↑(1) | |||||||||
|
| ||||||||||
| MCP-1 | CSF | ↓(2,3) | ↓(2,3) | |||||||
| Plasma | ↓(1,3) | ↓(1) | ||||||||
|
| ||||||||||
| MIP-1β | CSF | ↓(3) | ↓(3) | ↑(2) | ↑(2,3) | |||||
| Plasma | ↑(1) | ↑(3) | ||||||||
|
| ||||||||||
| sCD14 | CSF | ↓(2,3) | ↓(2) | ↑(3) | ↑(2,3) | ↓(3) | ||||
| Plasma | ↑(3) | ↓(1) | ↑(1) | |||||||