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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Virology. 2015 Mar 26;0:146–152. doi: 10.1016/j.virol.2015.03.013

Figure 1. Timeline for discovery of putative cytosolic DNA sensors and associated signaling molecules.

Figure 1

The chronology of the identification of intracellular DNA sensors is shown. DNA sensors are in red, key signaling proteins in green, and the RNA sensors Rig-I and MDA5 shown for comparison (orange). As detailed in the text, certain DNA sensors (boxed in grey here) have been confirmed to have a role in DNA- and/or DNA-virus dependent cytokine and IFN-I production in vivo, by using knockout mice.