Figure 1.
Overexpressed genes in AML patients with low levels of WT1 expression. Samples of peripheral blood from 30 newly diagnosed, untreated, AML patients were assayed for gene overexpression by quantitative real-time PCR as previously described.47 Data were reanalyzed to identify genes overexpressed at least 50-fold in those patients with less than 50-fold WT1 overexpression compared with the normal donors. Red: 50–99-fold overexpression; bright red: 100-fold or greater overexpression; black: not detected; white: transcript detected but less than 50-fold overexpressed compared with normal donors. CCNA1, cyclin A1; MSLN, mesothelin; PRAME, preferentially expressed antigen in melanoma; PRTN3, proteinase 3; WT1, Wilms tumor 1.