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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Immunobiology. 2014 Dec 30;220(6):823–832. doi: 10.1016/j.imbio.2014.12.011

Figure 7. Role of SREC-I in response to double stranded RNA.

Figure 7

Double stranded RNA species Poly I:C interacts with macrophages leading to recruitment of SREC-I and TLR3 to the cell surface where they form a membrane complex that interacts with c-Src. The latter kinase then regulates endocytosis of the SREC-I/TLR3/Poly I:C complexes in endosomes. The complex finally resides in endosomes with low intravesicular pH, marked with lysosomal protein LAMP1. TLR3 is able to signal from such complexes and launches NFkB, MAPK and IRF3 signaling. (IRF3 is activated by the kinase TBK1). Activated NFkB, AP-1 and C/EBPβ are known to interact with the IL-8 gene while activated IRF3 leads to synthesis of Ifn-β.